Bio-Gen® Cortico-Cancellous Granulate Gel by Bioteck

The Best Alternative to Autologous Bone

Bio-Gen®: Innovation in Bone Regeneration with Bioteck

When looking for an effective bone graft, Bio-Gen® by Bioteck stands out as one of the best options. This material breaks away from the paradigm of thermally treated heterologous biomaterials. Instead, Bio-Gen® is obtained through an exclusive enzymatic process at controlled temperatures, allowing the mineral component to remain completely intact while preserving bone collagen (type I collagen) in its hydrolyzed form. Additionally, its granulate syringe format facilitates clinical application.

Properties of Bio-Gen®

• High-Quality Raw Material: Manufactured with carefully selected materials to ensure the best results.
• Enzymatic Deantigenization: A process that removes any potential antigenic components without damaging the material’s structure.
• Unaltered Mineral Phase: Maintains the original mineral composition of the bone.
• Hydrolyzed Collagen: Preserves type I collagen in its natural form, promoting bone regeneration.
• Beta-Ray Sterilization: Ensures the material’s safety and purity.

Key Benefits of Bio-Gen®

• More Natural: Its composition mimics autologous bone, promoting physiological bone regeneration.
• Higher Predictability: Delivers reliable and reproducible results in regenerative procedures.
• Optimal Structure: Designed to integrate effectively into the patient’s bone tissue.
• Natural Regeneration Booster: Bio-Gen® granules integrate seamlessly, stimulating new bone formation without causing inflammatory reactions.

Histologies and Clinical Results

Histological images taken six months after a regenerative surgery demonstrate Bio-Gen®’s effectiveness. Black arrows highlight newly formed bone, while squares identify residual biomaterial.

University of Milan, Department of Biomedical, Surgical, and Dental Sciences

The samples show:

• Significant amounts of new bone formation.
• Perfect integration of Bio-Gen® granules.
• No inflammatory infiltrates.

Clinical and In Vitro Studies

Bio-Gen®, developed by Bioteck, integrates physiologically, enhancing the body’s regenerative potential. In an in vitro study conducted with bone marrow stem cells, Bio-Gen® was shown to promote differentiation into osteoprogenitor cells (osteoblasts) significantly more effectively than anorganic bovine bone, which loses its collagen component due to high-temperature treatment.

Cell differentiation measurement through alkaline phosphatase enzyme quantification.

Innovation in Granulate Syringe Format

The granulate syringe presentation of Bio-Gen® simplifies handling and application during surgical procedures. This design allows specialists to work quickly and efficiently, ensuring precise material distribution.

With Bio-Gen® by Bioteck, healthcare professionals have a reliable ally in bone regeneration, maximizing clinical outcomes and improving the patient experience.